Thiohydantoins, which are the sulfur analogues of hydantoins, are the privileged scaffolds in modern synthetic organic chemistry due to their important pharmacological properties  and their usage as pesticides, reagents for dyes, C-terminal protein sequencing and metal-cation complexation agents. [1]

In this project, the atroposelectivity observed in the synthesis of the axially chiral 2-thiohydantoin derivatives and the role of the solvent on the product distribution is rationalized with computational tools. This project is carried out in collaboration with Prof. I. Dogan (BU).

[1] Z.P. Haslak, S.A. Cinar, S. S. Ozbek, G. Monard, I. Dogan and V. Aviyente Org. Biomol. Chem., 2020, 18, 2233-2241.